Publications Biomedical research

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International (SCI) publications & book chapters of the Biomedical MR research group,

Department of Radiology, RUNMC (former UMCN). Publications from 1988 – now

2008

208. van Asten JJ, Cuijpers V, Hulsbergen-van de Kaa C, Soede-Huijbregts C, Witjes JA, Verhofstad A, Heerschap A. High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies. MAGMA. 2008 Nov;21(6):435-42. Epub 2008 Nov 25.PMID: 19031091
207. Klomp DW, Wijnen JP, Scheenen TW, Heerschap A Efficient 1H to 31P polarization transfer on a clinical 3T MR system. Magn Reson Med. 2008 Dec;60(6):1298-305
206. Gambarota G, Leenders W, Maass C, Wesseling P, van der Kogel B, van Tellingen O, Heerschap A. Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI. Br J Cancer. 2008 Jun 3;98(11):1784-9. Epub 2008 May 27.PMID: 18506183. IF : 4.5
205. Luts J, Poullet JB, Garcia-Gomez JM, Heerschap A, Robles M, Suykens JA, Van Huffel S. Effect of feature extraction for brain tumor classification based on short echo time 1H MR spectra.Magn Reson Med. 2008 Aug;60(2):288-98. PMID: 18666120
204. Van Cann EM, Rijpkema M, Heerschap A, van der Bilt A, Koole R, Stoelinga PJ. Quantitative dynamic contrast-enhanced MRI for the assessment of mandibular invasion by squamous cell carcinoma. Oral Oncol. 2008 Dec;44(12):1147-54. Epub 2008 May 16. PMID: 18485797. IF : 2.1
203. Mook OR, Jonker A, Strang AC, Veltien A, Gambarota G, Frederiks WM, Heerschap A, Van Noorden CJ. Noninvasive magnetic resonance imaging of the development of individual colon cancer tumors in rat liver. Biotechniques. 2008 Apr;44(4):529-35. PMID: 18476817 IF : 2.5
202. Scheenen TW, Heerschap A, Klomp DW.Towards (1)H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses. MAGMA. 2008 ;21(1-2):95-101. Epub 2008 Jan. PMID: 18210177. IF: 1.7
201. Nabuurs CI, Klomp DW, Veltien A, Kan HE, Heerschap A. Localized sensitivity enhanced in vivo 13C MRS to detect glucose metabolism in the mouse brain. Magn Reson Med. 2008;59(3):626-30. PMID: 18224699. IF: 3.5
200 **. van der Graaf M, Julià-Sapé M, Howe FA, Ziegler A, Majós C, Moreno-Torres A, Rijpkema M, Acosta D, Opstad KS, van der Meulen YM, Arús C, Heerschap A. MRS quality assessment in a multicentre study on MRS-based classification of brain tumours. NMR Biomed. 2008 Feb;21(2):148-58. PMID: 17458918. IF : 3.7
199. Claes A, Wesseling P, Jeuken J, Maass C, Heerschap A, Leenders WP. Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization. Mol Cancer Ther. 2008 Jan;7(1):71-8. Epub 2008 Jan 9. PMID: 18187807 . IF: 5.1
198. Scheenen TW, Klomp DW, Wijnen JP, Heerschap A. Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses. Magn Reson Med. 2008 Jan;59(1):1-6.PMID: 17969076 .
197 Claes A, Gambarota G, Hamans B, van Tellingen O, Wesseling P, Maass C, Heerschap A, Leenders W. Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment. Int J Cancer. 2008 May 1;122(9):1981-6. PMID: 18081012 .
196. Renema WK, Kan HE, Heerschap A. Is ATP elevated in patients with GAMT deficiency?AJNR Am J Neuroradiol. 2008 Feb;29(2):214; author reply 214. Epub 2007 Nov 16. PMID: 18024580.
195 **. Klomp DW, Kentgens AP, Heerschap A. Polarization transfer for sensitivity-enhanced MRS using a single radio frequency transmit channel. NMR Biomed. 2008 Jun;21(5):444-52. PMID: 17918206 .

2007

194. **. Scheenen TW, Heijmink SW, Roell SA, Hulsbergen-Van de Kaa CA, Knipscheer BC, Witjes JA, Barentsz JO, Heerschap A.Three-dimensional proton MR spectroscopy of human prostate at 3 T without endorectal coil: feasibility.Radiology. 2007 Nov;245(2):507-16. Epub 2007 Sep. PMID: 17848681. IF: 5.3
193. Scheenen TW, Vergeldt FJ, Heemskerk AM, Van As H. Intact plant magnetic resonance imaging to study dynamics in long-distance sap flow and flow-conducting surface area. Plant Physiol. 2007 Jun;144(2):1157-65. Epub 2007 Apr 20.
192. Heijmink SW, Futterer JJ, Hambrock T, Takahashi S, Scheenen TW, Huisman HJ, Hulsbergen-Van de Kaa CA, Knipscheer BC, Kiemeney LA, Witjes JA, Barentsz JO. Prostate cancer: body-array versus endorectal coil MR imaging at 3 T--comparison of image quality, localization, and staging performance.Radiology. 2007 Jul;244(1):184-95. Epub 2007 May 10.
191. Hooijmans CR, Rutters F, Dederen PJ, Gambarota G, Veltien A, van Groen T, Broersen LM, Lutjohann D, Heerschap A, Tanila H, Kiliaan AJ. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD). Neurobiol Dis. 2007 Jun 18.
190. Gambarota G, Veltien A, Klomp D, Van Alfen N, Mulkern RV, Heerschap A. Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla. Muscle Nerve. 2007 Jun 22.
189. Streijger F, in ‘t Zandt H.J.A, Renema W.K.J, Oerlemans F, Heerschap A, Kuiper J, Pluk H, Jost C, van der Zee C.E.E.M, and Wieringa B. “Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase–deficient Mice: Understanding CK’s Role in the Fuelling of Behavior and Learning” in Molecular System Bioenergetics: Energy for Life. Edited by Valdur Saks Copyright 8 2007 WILEY, chapter 10
188. Heijmink SW, Scheenen TW, Futterer JJ, Klomp DW, Heesakkers RA, Hulsbergen-van de Kaa CA, van Lin EN, Heerschap A, Barentsz JO. Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy. Invest Radiol. 2007 Jun;42(6):420-7.
187. Luts J, Heerschap A, Suykens JA, Van Huffel S. A combined MRI and MRSI based multiclass system for brain tumour recognition using LS-SVMs with class probabilities and feature selection. Artif Intell Med. 2007 Jun;40(2):87-102. Epub 2007 Apr 26.
186. van der Graaf M, Julia-Sape M, Howe FA, Ziegler A, Majos C, Moreno-Torres A, Rijpkema M, Acosta D, Opstad KS, van der Meulen YM, Arus C, Heerschap A. MRS quality assessment in a multicentre study on MRS-based classification of brain tumours. NMR Biomed. 2007 Apr 26.
185. Heerschap A, Kan HE, Nabuurs C.I.H.C, Renema WKJan, Isbrandt D, and Wieringa B. In Vivo Magnetic Resonance Spectroscopy of Transgenic Mice with Altered Expression of Guanidinoacetate Methyltransferase and Creatine Kinase Isoenzymes. Chapter 7 In “Creatine and Creatine Kinase in Health and Disease” Series: Subcellular Biochemistry , Vol. 46 Salomons, Gajja S.; Wyss, Markus (Eds.) 2007, Approx. 450 p., Hardcover. ISBN: 978-1-4020-6485-2
184. de Vries IJM, Lesterhuis, WJ, Barentsz JO, van Krieken JH, Raymakers RA, Oyen WJG, Adema GJ, Heerschap A, Hoogerbrugge PM, Punt CJA, Figdor CG. Het volgen van therapeutische cellen met magnetische resonantie. Nederlands Tijdschrift voor Hematologie 4 , nr 4 2007: 133- 138.
183. Kan HE, Meeuwissen E, van Asten JJ, Veltien A, Isbrandt D, Heerschap A. Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy. J Appl Physiol. 2007 Jun;102(6):2121-7. Epub 2007 Mar 8.
182. Renema WK, Kan HE, Wieringa B, Heerschap A. In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism. NMR Biomed. 2007 Jun;20(4):448-67.
181. Futterer JJ, Scheenen TW, Heijmink SW, Huisman HJ, Hulsbergen-Van de Kaa CA, Witjes JA, Heerschap A, Barentsz JO. Standardized Threshold Approach Using Three-Dimensional Proton Magnetic Resonance Spectroscopic Imaging in Prostate Cancer Localization of the Entire Prostate. Invest Radiol. 2007 Feb;42(2):116-122.
180. Verdijk P, Scheenen TW, Lesterhuis WJ, Gambarota G, Veltien AA, Walczak P, Scharenborg NM, Bulte JW, Punt CJ, Heerschap A, Figdor CG, de Vries IJ. Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines. Int J Cancer. 2007 Mar 1;120(5):978-84.
179. De Vos M, Laudadio T, Simonetti AW, Heerschap A, Van Huffel S. Fast nosologic imaging of the brain. J Magn Reson. 2007 Feb;184(2):292-301. Epub 2006 Nov 22.
178. van Laarhoven HW, Klomp DW, Rijpkema M, Kamm YL, Wagener DJ, Barentsz JO, Punt CJ, Heerschap A. Prediction of chemotherapeutic response of colorectal liver metastases with dynamic gadolinium-DTPA-enhanced MRI and localized 19F MRS pharmacokinetic studies of 5-fluorouracil. NMR Biomed. 2007 Apr;20(2):128-40
177. Heerschap A. “In Vivo Magnetic Resonance Spectroscopy in Clinical Oncology” in Cancer Drug Discovery and Development In Vivo Imaging of Cancer Therapy Edited by: A.F. Shields and P. Price © Humana Press Inc., Totowa, NJ, 2007, chapter 13
176. Devos, A., Van Huffel, S., Simonetti, A.W., Van der Graaf, M., Heerschap, A. & Buydens, L.M.C., "Classification of brain tumours by pattern recognition of Magnetic Resonance Imaging and Spectroscopy data" in: Outcome Prediction in Cancer (A.F.G. Taktak and A.C. Fisher, Eds), Elsevier B.V. (Publisher), 2007, chapter 11, 285-318

2006

175. Engelke, U.F.H., Kremer, B., Kluijtmans, L.A.J., Van der Graaf, M., Morava, E, Loupatty, F.J., Wanders, R.J.A., Moskau, D., Loss, S., Van den Bergh, E. & Wevers, R.A. "NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism", NMR Biomed. 19 (2006), 271-278.
174. Willemsen, M.A.A.P., Engelke, U.F.H., Van der Graaf, M. & Wevers, R.A. Methylsulfonylmethane (MSM) ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid, Neuropediatrics 2006; 37 (5): 312-314.
173. Hamans BC, Barth M, Leenders WP, Heerschap A. Contrast enhanced susceptibility weighted imaging (CE-SWI) of the mouse brain using ultrasmall superparamagnetic ironoxide particles (USPIO). Z Med Phys. 2006;16(4):269-74.
172. Barentsz J, Verdijk P, de Vries I, Lesterhuis W, Scheenen T, Boerman O, Oyen W, Adema G, van Krieken J, Bulte J, Punt C, Heerschap A, Figdor C. CMR 2005: 9.07: In vivo MR tracking of magnetically labeled dendritic cells: first clinical experience. Contrast Media Mol Imaging. 2006 Mar;1(2):79. No abstract available..
171. Klomp D, van Laarhoven H, Scheenen T, Kamm Y, Heerschap A. Quantitative (19)F MR spectroscopy at 3T to detect heterogeneous capecitabine metabolism in human liver. NMR Biomed. 2006 Nov 27; [Epub ahead of print]
170. De Vos M, Laudadio T, Simonetti AW, Heerschap A, Van Huffel S. Fast nosologic imaging of the brain. J Magn Reson. 2006 Nov 20.
169. Kan HE, van der Graaf M, Klomp DW, Vlak MH, Padberg GW, Heerschap A. Intake of (13)C-4 creatine enables simultaneous assessment of creatine and phosphocreatine pools in human skeletal muscle by (13)C MRspectroscopy. Magn Reson Med. 2006 Nov;56(5):953-7.
168. Kemper EM, Leenders W, Kusters B, Lyons S, Buckle T, Heerschap A, Boogerd W, Beijnen JH, van Tellingen O. Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies. Eur J Cancer. 2006 Dec;42(18):3294-303. Epub 2006 Oct 5.
167. Futterer JJ, Heijmink SW, Scheenen TW, Veltman J, Huisman HJ, Vos P, de Kaa CA, Witjes JA, Krabbe PF, Heerschap A, Barentsz JO. Prostate Cancer Localization with Dynamic Contrast-enhanced MR Imaging and Proton MR Spectroscopic Imaging. Radiology. 2006 Nov;241(2):449-58. Epub 2006 Sep 11.
166. van Laarhoven HW, Gambarota G, Lok J, Lammens M, Kamm YL, Wagener T, Punt CJ, van der Kogel AJ, Heerschap A. Carbogen breathing differentially enhances blood plasma volume and 5-Fluorouracil uptake in two murine colon tumor models with a distinct vascular structure. Neoplasia. 2006 Jun;8(6):477-87
165. Tate AR, Underwood J, Acosta DM, Julia-Sape M, Majos C, Moreno-Torres A, Howe FA, van der Graaf M, Lefournier V, Murphy MM, Loosemore A, Ladroue C, Wesseling P, Luc Bosson J, Cabanas ME, Simonetti AW, Gajewicz W, Calvar J, Capdevila A, Wilkins PR, Bell BA, Remy C, Heerschap A, Watson D, Griffiths JR, Arus C. Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra. NMR Biomed. 2006 Jun;19(4):411-34.
164. Arias-Mendoza F, Payne GS, Zakian KL, Schwarz AJ, Stubbs M, Stoyanova R, Ballon D, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR. In vivo (31)P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. NMR Biomed. 2006 Jun;19(4):504-12
163.Gambarota G, van Laarhoven HW, Philippens M, Lok J, van der Kogel A, Punt CJ, Heerschap A. Assessment of absolute blood volume in carcinoma by USPIO contrast-enhanced MRI. Magn Reson Imaging. 2006 Apr;24(3):279-86. Epub 2006 Feb 2.
162. van Laarhoven HW, Gambarota G, Heerschap A, Lok J, Verhagen I, Corti A, Toma S, Gallo Stampino C, van der Kogel A, Punt CJ. Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas. Invest New Drugs. 2006 Jan;24(1):27-36.
161. Klomp DW, Renema WK, van der Graaf M, de Galan BE, Kentgens AP, Heerschap A. Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla. Magn Reson Med. 2006 Feb;55(2):271-8.
160. van Laarhoven HW, Kaanders JH, Lok J, Peeters WJ, Rijken PF, Wiering B, Ruers TJ, Punt CJ, Heerschap A, van der Kogel AJ. Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer.Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):473-82. Epub 2005 Oct 19.
159. van Lin EN, Futterer JJ, Heijmink SW, van der Vight LP, Hoffmann AL, van Kollenburg P, Huisman HJ, Scheenen TW, Witjes JA, Leer JW, Barentsz JO, Visser AG. IMRT boost dose planning on dominant intraprostatic lesions: gold marker-based three-dimensional fusion of CT with dynamic contrast-enhanced and 1H-spectroscopic MRI. Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):291-303.
158 Abbink EJ, Graaf J, Haan JH, Heerschap A, Stalenhoef AF, Tack CJ. Effects of pioglitazone in familial combined hyperlipidaemia. J Intern Med. 2006 Jan;259(1):107-16.

2005

157. Devos, A, van Huffel, S, Simonetti, AW, van der Graaf, M, Heerschap A, and Buydens, L. Classification of brain tumours by pattern recognition of Magnetic Resonance Imaging and Spectroscopy. In: A Multi-Perspective View on Outcome Prediction in Cancer. Azzam Taktak, Ed., Elsevier Publishing Company, 2005, chapter 8.
156.Huisman HJ, Futterer JJ, van Lin EN, Welmers A, Scheenen TW, van Dalen JA, Visser AG, Witjes JA, Barentsz JO. Prostate cancer: precision of integrating functional MR imaging with radiation therapy treatment by using fiducial gold markers. Radiology. 2005 Jul;236(1):311-7.
155. de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, Scheenen TW, Punt CJ, Heerschap A, Figdor CG. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol. 2005 Nov;23(11):1407-1413. Epub 2005 Oct 30.
154. van Laarhoven HW, de Geus-Oei LF, Wiering B, Lok J, Rijpkema M, Kaanders JH, Krabbe PF, Ruers T, Punt CJ, van der Kogel AJ, Oyen WJ, Heerschap A. Gadopentetate Dimeglumine and FDG Uptake in Liver Metastases of Colorectal Carcinoma as Determined with MR Imaging and PET. Radiology. 2005 Oct;237(1):181-8.
153. Gambarota G, van der Graaf M, Klomp D, Mulkern RV, Heerschap A. Echo-time independent signal modulations using PRESS sequences: A new approach to spectral editing of strongly coupled AB spin systems. J Magn Reson. 2005 Sep 15; [Epub ahead of print
152. van Laarhoven HW, Bussink J, Lok J, Verhagen I, Punt CJ, Heerschap A, Kaanders JH, van der Kogel AJ. Modulation of hypoxia in murine liver metastases of colon carcinoma by nicotinamide and carbogen. Radiat Res. 2005 Sep;164(3):245-9.
151. Gambarota G, Philippens M, Cairns BE, Dong XD, Renema WK, Heerschap A. MRS assessment of glutamate clearance in a novel masticatory muscle pain model. NMR Biomed. 2005 Oct;18(6):345-51.
150. Scheenen TW, Gambarota G, Weiland E, Klomp DW, Futterer JJ, Barentsz JO, Heerschap A. Optimal timing for in vivo 1H-MR spectroscopic imaging of the human prostate at 3T.Magn Reson Med. 2005 Jun;53(6):1268-74.
149. van Laarhoven HW, Punt CJ, Kamm YJ, Heerschap A. Monitoring fluoropyrimidine metabolism in solid tumors with in vivo (19)F magnetic resonance spectroscopy.Crit Rev Oncol Hematol. 2005 Jun 24;
148. Serlie MJ, de Haan JH, Tack CJ, Verberne HJ, Ackermans MT, Heerschap A, Sauerwein HP. Glycogen synthesis in human gastrocnemius muscle is not representative of whole-body muscle glycogen synthesis. Diabetes. 2005 May;54(5):1277-82.
147. Devos A, Simonetti AW, van der Graaf M, Lukas L, Suykens JA, Vanhamme L, Buydens LM, Heerschap A, Van Huffel S. The use of multivariate MR imaging intensities versus metabolic data from MR spectroscopic imaging for brain tumour classification. J Magn Reson. 2005 Apr;173(2):218-28.
146. Kan HE, Buse-Pot TE, Peco R, Isbrandt D, Heerschap A, de Haan A. Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice. Am J Physiol Cell Physiol. 2005 Jul;289(1):C113-9. Epub 2005 Mar 2.
145. Simonetti AW, Melssen WJ, Szabo de Edelenyi F, van Asten JJ, Heerschap A, Buydens LM. Combination of feature-reduced MR spectroscopic and MR imaging data for improved brain tumor classification. NMR Biomed. 2005 Feb;18(1):34-43.

2004

144 Devos A, Lukas L, Simonetti AW, Suykens JA, Vanhamme L, van der Graaf M, Buydens LM, Heerschap A, Van Huffel S. Does the combination of magnetic resonance imaging and spectroscopic imaging improve the classification of brain tumours? Conf Proc IEEE Eng Med Biol Soc. 2004;1:407-10.
143. Mulkern RV, Chen NK, Oshio K, Panych LP, Rybicki FJ, Gambarota G. Fast spectroscopic imaging strategies for potential applications in fMRI. Magn Reson Imaging. 2004 Dec;22(10):1395-1405.
142. Philippens ME, Gambarota G, Pikkemaat JA, Peeters WJ, Kogel AJ, Heerschap A. Characterization of late radiation effects in the rat thoracolumbar spinal cord by MR imaging using USPIO. MAGMA. 2004 Dec 21; [Epub ahead of print]
141. Gambarota G, Veltien A, Laarhoven HV, Philippens M, Jonker A, Mook OR, Frederiks WM, Heerschap A. Measurements of T(1) and T(2) relaxation times of colon cancer metastases in rat liver at 7 T. MAGMA. 2004 Dec 1; [Epub ahead of print]
140. Futterer JJ, Scheenen TW, Huisman HJ, Klomp DW, van Dorsten FA, Hulsbergen-van de Kaa CA, Witjes JA, Heerschap A, Barentsz JO. Initial experience of 3 tesla endorectal coil magnetic resonance imaging and 1H-spectroscopic imaging of the prostate. Invest Radiol. 2004 Nov;39(11):671-80.
139. Devos A, Lukas L, Suykens JA, Vanhamme L, Tate AR, Howe FA, Majos C, Moreno-Torres A, van der Graaf M, Arus C, Van Huffel S. Classification of brain tumours using short echo time 1H MR spectra J Magn Reson. 2004 Sep;170(1):164-75
138. Leenders WP, Kusters B, Verrijp K, Maass C, Wesseling P, Heerschap A, Ruiter D, Ryan A, De Waal R. Antiangiogenic Therapy of Cerebral Melanoma Metastases Results in Sustained Tumor Progression via Vessel Co-Option. Clin Cancer Res. 2004 Sep 15;10(18):6222-30.
137. Arias-Mendoza F, Zakian K, Schwartz A, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR; Cooperative Group on MRS Applications in Cancer. Methodological standardization for a multi-institutional in vivo trial of localized (31)P MR spectroscopy in human cancer research. In vitro and normal volunteer studies. NMR Biomed. 2004 Oct;17(6):382-91.
136. In 't Zandt HJ, Renema WK, Streijger F, Jost C, Klomp DW, Oerlemans F, Van Der Zee CE, Wieringa B, Heerschap A. Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: a quantitative in vivo 1H and 31P magnetic resonance study. J Neurochem. 2004 Sep;90(6):1321-30
135. Van Laarhoven HW, Bussink J, Lok J, Punt CJ, Heerschap A, Van Der Kogel AJ. Effects of nicotinamide and carbogen in different murine colon carcinomas: Immunohistochemical analysis of vascular architecture and microenvironmental parameters. Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):310-21
134. Van Der Graaf M, Janssen SW, Van Asten JJ, Hermus AR, (Fred) Sweep CG, Pikkemaat JA, Martens GJ, Heerschap A. Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo (1)H magnetic resonance spectroscopy. NMR Biomed. 2004;17(6):405-10.
133 Kan HE, Renema WK, Isbrandt D, Heerschap A. Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase. J Physiol. 2004 0ct 1; 560 (Pt 1): 219-29
132. Van Dorsten FA, Van Der Graaf M, Engelbrecht MR, Van Leenders GJ, Verhofstad A, Rijpkema M, De La Rosette JJ, Barentsz JO, Heerschap A. Combined quantitative dynamic contrast-enhanced MR imaging and (1)H MR spectroscopic imaging of human prostate cancer. J Magn Reson Imaging. 2004 Aug;20(2):279-87
131. Hartman EH, Pikkemaat JA, Van Asten JJ, Vehof JW, Heerschap A, Oyen WJ, Spauwen PH, Jansen JA. Demineralized Bone Matrix-Induced Ectopic Bone Formation in Rats: In Vivo Study with Follow-up by Magnetic Resonance Imaging, Magnetic Resonance Angiography, and Dual-Energy X-Ray Absorptiometry. Tissue Eng. 2004 May-Jun;10(5-6):747-54.
130. Lukas L, Devos A, Suykens JA, Vanhamme L, Howe FA, Majos C, Moreno-Torres A, Van Der Graaf M, Tate AR, Arus C, Van Huffel S. Brain tumor classification based on long echo proton MRS signals. Artif Intell Med. 2004 May;31(1):73-89.
129. Scheenen TW, Klomp DW, Roll SA, Futterer JJ, Barentsz JO, Heerschap A. Fast acquisition-weighted three-dimensional proton MR spectroscopic imaging of the human prostate.Magn Reson Med. 2004 Jul;52(1):80-88
128. Kok RD, De Vries MM, Heerschap A, Van Den Berg PP. Absence of harmful effects of magnetic resonance exposure at 1.5 T in utero during the third trimester of pregnancy: a follow-up study. Magn Reson Imaging. 2004 Jul;22(6):851-854.
127. Rijpkema M, Schuuring J, Bernsen P, Bernsen HJ, Kaanders JH, Van Der Kogel AJ, Heerschap A. BOLD MRI response to hypercapnic hyperoxia in patients with meningiomas: correlation with Gadolinium-DTPA uptake rate. Magn Reson Imaging. 2004 Jul;22(6):761-767.
126. Heerschap A, Sommers MG, in 't Zandt HJ, Renema WK, Veltien AA, Klomp DW. Nuclear magnetic resonance in laboratory animals. Methods Enzymol. 2004;385:41-63.
125 Klomp DW, Van Der Graaf M, Willemsen MA, Van Der Meulen YM, Kentgens AP, Heerschap A. Transmit/receive headcoil for optimal (1)H MR spectroscopy of the brain in paediatric patients at 3T. MAGMA. 2004 Sep;17(1):1-4. Epub 2004 May 24
124 Willemsen MA, Van Der Graaf M, Van Der Knaap MS, Heerschap A, Van Domburg PH, Gabreels FJ, Rotteveel JJ. MR imaging and proton MR spectroscopic studies in Sjogren-Larsson syndrome: characterization of the leukoencephalopathy. AJNR Am J Neuroradiol. 2004 Apr;25(4):649-57.
123 Schmidt A, Marescau B, Boehm EA, Renema WK, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, Ullrich K, Waldschutz R, Heerschap A, De Deyn PP, Neubauer S, Isbrandt D. Severely altered guanidino compound levels, disturbed body weight homeostasis, and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum Mol Genet. 2004 May 1;13(9):905-21.
122 Kamm YJ, Heerschap A, Van Den Bergh EJ, Wagener DJ. 19F-magnetic resonance spectroscopy in patients with liver metastases of colorectal cancer treated with 5-fluorouracil. Anticancer Drugs. 2004 Mar;15(3):229-233

2003

121. De Haan JH, Klomp DW, Tack CJ, Heerschap A. Optimized detection of changes in glucose-6-phosphate levels in human skeletal muscle by 31P MR spectroscopy. Magn Reson Med. 2003 Dec;50(6):1302-6.
120. van Laarhoven HW, Klomp DW, Kamm YJ, Punt CJ, Heerschap A. In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength. Cancer Res. 2003 Nov 15;63(22):7609-12.
119. Kusters B, de Waal RM, Wesseling P, Verrijp K, Maass C, Heerschap A, Barentsz JO, Sweep F, Ruiter DJ, Leenders WP. Differential effects of vascular endothelial growth factor A isoforms in a mouse brain metastasis model of human melanoma. Cancer Res. 2003 Sep 1;63(17):5408-13.
118. Simonetti AW, Melssen WJ, van der Graaf M, Postma GJ, Heerschap A, Buydens LM. A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy. Anal Chem. 2003 Oct 15;75(20):5352-61
117. Renema WK, Schmidt A, Van Asten JJ, Oerlemans F, Ullrich K, Wieringa B, Isbrandt D, Heerschap A.MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: Validation of an animal model to study creatine deficiency.Magn Reson Med. 2003 Nov;50(5):936-43.
116. Renema WK, Klomp DW, Philippens ME, Van Den Bergh AJ, Wieringa B, Heerschap A. Magnetization transfer effect on the creatine methyl resonance studied by CW off-resonance irradiation in human skeletal muscle on a clinical MR system. Magn Reson Med. 2003; 50(3):468-73.
115. Van Laarhoven HW, Rijpkema M, Punt CJ, Ruers TJ, Hendriks JC, Barentsz JO, Heerschap A. Method for quantitation of dynamic MRI contrast agent uptake in colorectal liver metastases.J Magn Reson Imaging. 2003 Sep;18(3):315-20.
114. Kamm YJ, Peters GJ, Hull WE, Punt CJ, Heerschap A. Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma. Br J Cancer. 2003 Aug 18;89(4):754-62.
113. Van Cappellen Van Walsum AM, Rijpkema M, Heerschap A, Oeseburg B, Nijhuis JG, Jongsma HW. Cerebral (31)P magnetic resonance spectroscopy and systemic acid-base balance during hypoxia in fetal sheep. Pediatr Res. 2003 Nov;54(5):747-52. Epub 2003 Aug 06
112. Klomp DW, Van Laarhoven HW, Kentgens AP, Heerschap A. Optimization of localized 19F magnetic resonance spectroscopy for the detection of fluorinated drugs in the human liver. Magn Reson Med. 2003 Aug;50(2):303-8.
111. Heerschap A, Kok RD, van den Berg PP. Antenatal proton MR spectroscopy of the human brain in vivo. Childs Nerv Syst. 2003 Aug;19(7-8):418-21. Epub 2003 Jun 17
110. Leenders W, Kusters B, Pikkemaat J, Wesseling P, Ruiter D, Heerschap A, Barentsz J, de Waal RM. Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI. Int J Cancer. 2003 Jul 1;105(4):437-43.
109. Kok RD, Steegers-Theunissen RP, Eskes TK, Heerschap A, van den Berg PP. Decreased relative brain tissue levels of inositol in fetal hydrocephalus. Am J Obstet Gynecol. 2003 Apr;188(4):978-80.
108. Robinson SP, Rijken PF, Howe FA, McSheehy PM, Van Der Sanden BP, Heerschap A, Stubbs M, Van Der Kogel AJ, Griffiths JR.Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry. J Magn Reson Imaging. 2003 Apr;17(4):445-54.
107. In 't Zandt HJ, De Groof AJ, Renema WK, Oerlemans FT, Klomp DW, Wieringa B, Heerschap A. Presence of (phospho)creatine in developing and adult skeletal muscle of mice without mitochondrial and cytosolic muscular creatine kinase isoforms. J Physiol. 2003 May 1;548(Pt 3):847-58. Epub 2003 Mar 14.
106.Cairns B, Gambarota G, Dunning P, Mulkern RV, Berde C. Activation of peripheral excitatory amino acid receptors decreases the duration of local anesthesia.Anesthesiology. 2003;98(2):521-9.
105. Rijpkema M, Schuuring J, Van Der Meulen Y, Van Der Graaf M, Bernsen H, Boerman R, Van Der Kogel A, Heerschap A. Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging. NMR Biomed. 2003 Feb;16(1):12-8
104. Witjes H, Rijpkema M, Van Der Graaf M, Melssen W, Heerschap A, Buydens L. Multispectral magnetic resonance image analysis using principal component and linear discriminant analysis. J Magn Reson Imaging. 2003 Feb;17(2):261-9

2002

103. Hartman EH, Pikkemaat JA, Vehof JW, Heerschap A, Jansen JA, Spauwen PH. In Vivo Magnetic Resonance Imaging Explorative Study of Ectopic Bone Formation in the Rat. Tissue Eng. 2002 Dec;8(6):1029-1036.
102. Simonetti AW, Melssen WJ, van der Graaf M, Heerschap A, Buydens LM. Automated correction of unwanted phase jumps in reference signals which corrupt MRSI spectra after eddy current correction. J Magn Reson. 2002 Dec;159(2):151-7.
101. Kok RD, Van Den Berg PP, Van Den Bergh AJ, Nijland R, Heerschap A. Maturation of the human fetal brain as observed by 1H MR spectroscopy. Magn Reson Med. 2002 ;48(4):611-6.
100. Rijpkema M, Kaanders JH, Joosten FB, van der Kogel AJ, Heerschap A. Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1185-91.
99. Schuuring J, Rijpkema M, Bernsen H, Bernsen P, van der Maazen R, Kaanders J, van der Kogel A, Heerschap A. Effect of breathing a hyperoxic hypercapnic gas mixture on the oxygenation of meningiomas; preliminary results. J Neurooncol. 2002 Apr;57(2):127-32.
98. Houtman CJ, Heerschap A, Zwarts MJ, Stegeman DF. An additional phase in PCr use during sustained isometric exercise at 30% MVC in the tibialis anterior muscle. NMR Biomed. 2002 Jun;15(4):270-7.
97. Shukla-Dave A, Poptani H, Loevner L, Mancuso A, Serrai H, Rosenthal D, Kilger A, Nelson D, Zakian KL, Arias-Mendoza F, Rijpkema M, Koutcher JA, Brown TR, Heerschap A, Glickson JD. Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels. Acad Radiol. 2002 Jun;9(6):688-94.
96. Jost CR, Van Der Zee CE, In 't Zandt HJ, Oerlemans F, Verheij M, Streijger F, Fransen J, Heerschap A, Cools AR, Wieringa B. Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. Eur J Neurosci. 2002 May;15(10):1692-1706.
95. Kok RD, van den Berg PP, van den Bergh AJ, Nijland R, Heerschap A. MR spectroscopy in the human fetus. Radiology. 2002 May; 223(2):584; 584-5.
94. Verhoye M, van Der Sanden BP, Rijken PF, Peters HP, Van Der Kogel AJ, Pee G, Vanhoutte G, Heerschap A, Van Der Linden A. Assessment of the neovascular permeability in glioma xenografts by dynamic T(1) MRI with Gadomer-17. Magn Reson Med. 2002 Feb;47(2):305-13.
93. Legtenberg RJ, Houston R, Heerschap A, Oeseburg B, Smits P. Glibenclamide attenuates ischemia-induced acidosis and loss of cardiac function in rats. Eur J Pharmacol. 2002 2;434(1-2):35-42.
92. Rijpkema M, Kaanders J. Functional MR imaging of laryngeal cancer. In: Imaging of the larynx. Hermans R (Ed.), Springer, Berlin, 175-184, 2002.

2001

91. Kok RD, Van Den Bergh AJ, Heerschap A, Nijland R, Van Den Berg PP. Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy. Am J Obstet Gynecol. 2001 Nov;185(5):1011-5.
90. Klomp DW, Collins DJ, van den Boogert HJ, Schwarz A, Rijpkema M, Prock T, Payne GS, Leach MO, Heerschap A. Radio-frequency probe for 1H decoupled 31P MRS of the head and neck region, Magn Reson Imaging. 2001, jun ; 19 (5),755-759
89. Rijpkema M, Kaanders JH, Joosten FB, van Der Kogel AJ, Heerschap A. Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. J Magn Reson Imaging. 2001 Oct;14(4):457-63.
88. Houtman CJ, Heerschap A, Zwarts MJ, Stegeman DF. pH heterogeneity in tibial anterior muscle during isometric activity studied by 31P-NMR spectroscopy. J Appl Physiol. 2001;91(1):191-200.
87. in 't Zandt H, van Der Graaf M, Heerschap A. Common processing of in vivo MR spectra. NMR Biomed. 2001 Jun;14(4):224-32.
86. Willemsen MA, Lutt MA, Steijlen PM, Cruysberg JR, van der Graaf M, Nijhuis-van der Sanden MW, Pasman JW, Mayatepek E, Rotteveel JJ. Clinical and biochemical effects of zileuton in patients with the Sjogren-Larsson syndrome. Eur J Pediatr. 2001 Dec;160(12):711-7
85. van Luijk P, Bijl H, Coppes R, van der Kogel A, Konings A, Pikkemaat J, Schippers J. Techniques for precision irradiation of the lateral half of the rat cervical spinal cord using 150 meV protons. Phys Med Biol. 2001 Nov;46(11):2857-71.

2000

84. Janssen E, Dzeja PP, Oerlemans F, Simonetti AW, Heerschap A, de Haan A, Rush PS, Terjung RR, Wieringa B, Terzic A. Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement. EMBO J. 2000 Dec 1;19(23):6371-81.
83. Schwarz AJ, Rijpkema M, Collins DJ, Payne GS, Prock T, Woodward AC, Heerschap A, Leach MO. SAR and tissue heating with a clinical (31)P MRS protocol using surface coils, adiabatic pulses, and proton-decoupling. Magn Reson Med. 2000 Nov;44(5):692-700.
82. Engelbrecht MR, Barentsz JO, Jager GJ, van der Graaf M, Heerschap A, Sedelaar J, Aarnink R, de la Rosette JJ. Prostate cancer staging using imaging. BJU Int. 2000 ;86 Suppl 1:123-34. Review.
81. van der Graaf M, Schipper RG, Oosterhof GO, Schalken JA, Verhofstad AA, Heerschap A. Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer. MAGMA. 2000 Jul;10(3):153-9.
80. Kamm YJ, Heerschap A, Wagener DJ. Effect of carbogen breathing on the pharmacodynamics of 5-fluorouracil in a murine colon carcinoma. Eur J Cancer. 2000 Jun;36(9):1180-6.
79. van der Sanden BP, Rozijn TH, Rijken PF, Peters HP, Heerschap A, van der Kogel AJ, Bovee WM. Noninvasive assessment of the functional neovasculature in 9L-glioma growing in rat brain by dynamic 1H magnetic resonance imaging of gadolinium uptake. J Cereb Blood Flow Metab. 2000 May;20(5):861-70.
78. Witjes H, Melssen WJ, in 't Zandt HJ, van der Graaf M, Heerschap A, Buydens LM. Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets. J Magn Reson. 2000 May;144(1):35-44.
77. Willemsen MA, Rotteveel JJ, Steijlen PM, Heerschap A, Mayatepek E. 5-Lipoxygenase inhibition: a new treatment strategy for Sjogren-Larsson syndrome.Neuropediatrics. 2000 Feb;31(1):1-3.
76. in 't Zandt HJ, Klomp DW, Oerlemans F, Wieringa B, Hilbers CW, Heerschap A. Proton MR spectroscopy of wild-type and creatine kinase deficient mouse skeletal muscle: dipole-dipole coupling effects and post-mortem changes. Magn Reson Med. 2000 Apr;43(4):517-24.
75. van den Bergh AJ, van den Boogert HJ, Heerschap A. Skin temperature increase during local exposure to high-power RF levels in humans. Magn Reson Med. 2000 Mar;43(3):488-90.
74. Van Den Bergh AJ, Tack CJ, Van Den Boogert HJ, Vervoort G, Smits P, Heerschap A. Assessment of human muscle glycogen synthesis and total glucose content by in vivo 13C MRS. Eur J Clin Invest. 2000 Feb;30(2):122-8.
73. Gillies RJ, Bhujwalla ZM, Evelhoch J, Garwood M, Neeman M, Robinson SP, Sotak CH, Van Der Sanden B. Applications of magnetic resonance in model systems: tumor biology and physiology. Neoplasia. 2000 Jan-Apr;2(1-2):139-51. Review.

1999

72. Heerschap A, Houtman C, in 't Zandt HJ, van den Bergh AJ, Wieringa B. Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle. Proc Nutr Soc. 1999 Nov;58(4):861-70. Review.
71. van Cappellen AM, Heerschap A, Nijhuis JG, Oeseburg B, Jongsma HW. Hypoxia, the subsequent systemic metabolic acidosis, and their relationship with cerebral metabolite concentrations: An in vivo study in fetal lambs with proton magnetic resonance spectroscopy. Am J Obstet Gynecol. 1999 Dec;181(6):1537-45.
70. Van der Graaf M, van den Boogert HJ, Jager GJ, Barentsz JO, Heerschap A. Human prostate: multisection proton MR spectroscopic imaging with a single spin-echo sequence--preliminary experience. Radiology. 1999 Dec;213(3):919-25.
69. Rozijn TH, van der Sanden BP, Heerschap A, Creyghton JH, Bovee WM. Determination of in vivo rat muscle Gd-DTPA relaxivity at 6.3 T. MAGMA. 1999; 9(1-2):65-71.
68. in 't Zandt HJ, Oerlemans F, Wieringa B, Heerschap A. Effects of ischemia on skeletal muscle energy metabolism in mice lacking creatine kinase monitored by in vivo 31P nuclear magnetic resonance spectroscopy. NMR Biomed. 1999 Oct;12(6):327-34.
67. Barentsz JO, Engelbrecht M, Jager GJ, Witjes JA, de LaRosette J, van Der Sanden BP, Huisman HJ, Heerschap A. Fast dynamic gadolinium-enhanced MR imaging of urinary bladder and prostate cancer. J Magn Reson Imaging. 1999 Sep;10(3):295-304. Review.
66. van der Sanden BP, Heerschap A, Hoofd L, Simonetti AW, Nicolay K, van der Toorn A, Colier WN, van der Kogel AJ. Effect of carbogen breathing on the physiological profile of human glioma xenografts.Magn Reson Med. 1999 Sep;42(3):490-9.
65. van der Sanden BP, in't Zandt HJ, Hoofd L, de Graaf RA, Nicolay K, Rijken PF, van der Kogel AJ, Heerschap A. Global HDO uptake in human glioma xenografts is related to the perfused capillary distribution. Magn Reson Med. 1999 Sep;42(3):479-89.
64. Rubio-Gozalbo ME, Heerschap A, Trijbels JM, De Meirleir L, Thijssen HO, Smeitink JA. Proton MR spectroscopy in a child with pyruvate dehydrogenase complex deficiency. Magn Reson Imaging. 1999 Jul;17(6):939-44.
63. van der Sanden BP, Heerschap A, Simonetti AW, Rijken PF, Peters HP, Stuben G, van der Kogel AJ. Characterization and validation of noninvasive oxygen tension measurements in human glioma xenografts by 19F-MR relaxometry. Int J Radiat Oncol Biol Phys. 1999;44(3):649-58.
62. van Domburg PH, Willemsen MA, Rotteveel JJ, de Jong JG, Thijssen HO, Heerschap A, Cruysberg JR, Wanders RJ, Gabreels FJ, Steijlen PM. Sjogren-Larsson syndrome: clinical and MRI/MRS findings in FALDH-deficient patients. Neurology. 1999 Apr 22;52(7):1345-52.
61. Moolenaar SH, Poggi-Bach J, Engelke UF, Corstiaensen JM, Heerschap A, de Jong JG, Binzak BA, Vockley J, Wevers RA. Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study. Clin Chem. 1999 Apr;45(4):459-64.

1998

60. Van den Bergh AJ, van den Boogert HJ, Heerschap A. Heteronuclear cross polarization for enhanced sensitivity of in vivo 13C MR spectroscopy on a clinical 1.5 T MR system. J Magn Reson. 1998 Nov;135(1):93-8.
59. Rozijn TH, van der Sanden BP, Heerschap A, Creyghton JH, Bovee WM. Influence of the pharmacokinetic model on the quantification of the Gd-DTPA uptake rate in brain tumours using direct T1 measurements. MAGMA. 1998 Aug;6(1):37-43.
58. van Cappellen van Walsum AM, Heerschap A, Nijhuis JG, Oeseburg B, Jongsma HW. Proton magnetic resonance spectroscopy of fetal lamb brain during hypoxia. Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):756-7.
57. Steeghs K, Oerlemans F, de Haan A, Heerschap A, Verdoodt L, de Bie M, Ruitenbeek W, Benders A, Jost C, van Deursen J, Tullson P, Terjung R, Jap P, Jacob W, Pette D, Wieringa B. Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies. Mol Cell Biochem. 1998 Jul;184(1-2):183-94.
56. Massuger LF, van Vierzen PB, Engelke U, Heerschap A, Wevers R. 1H-magnetic resonance spectroscopy: a new technique to discriminate benign from malignant ovarian tumors. Cancer. 1998 May 1;82(9):1726-30.
55. van den Bergh AJ, van den Boogert HJ, Heerschap A. Calibration of the 1H decoupling field strength and experimental evaluation of the specific RF absorption rate in 1H-decoupled human 13C-MRS. Magn Reson Med. 1998 Apr;39(4):642-6.
54. Heerschap A, Salemink P. Investigating NMR as a non-invasive tool in animal experimentation (DACH Autumn meeting 1997). Comp Haematol Int 1998; 8; 117 – 119
53. in 't Zandt HJ, Wieringa B, Heerschap A. Creatine kinase knockout mice--what is the phenotype: skeletal muscle. MAGMA. 1998 Sep;6(2-3):122-3.
52. C.J. Houtman, A. Heerschap, R.A. Wevers, D.F. Stegeman. NMR spectroscopy in the study of muscle fatigue. In : Blickhan R, Wisser, A., Nachtigall, W. (Eds.), Biona Report 13 Motion systems, Proceedings I Intern Confer. On Motion Systems, Innovationskolleg Bewegungssysteme, Jena (Germany), September 1997, 23 - 24 (1998)
51. A. Heerschap. Een Magnetische Blik op het Leven. KU Nijmegen, July 1999. Text Inaugural lecture.
50. Jager GJ, Barentsz JO, Heerschap A. Clinical aspects of MR in prostate cancer. Jager GJ, Barentsz JO, Heerschap A editors. Blackwell, Berlin, London New York. 1998

1997

49. Steeghs K, Benders A, Oerlemans F, de Haan A, Heerschap A, Ruitenbeek W, Jost C, van Deursen J, Perryman B, Pette D, Bruckwilder M, Koudijs J, Jap P, Veerkamp J, Wieringa B. Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell. 1997 Apr 4;89(1):93-103.
48. van der Graaf M, Jager GJ, Heerschap A. Removal of the outer lines of the citrate multiplet in proton magnetic resonance spectra of the prostatic gland by accurate timing of a point-resolved spectroscopy pulse sequence.MAGMA. 1997 Mar;5(1):65-9.
47. Heerschap A, Jager GJ, van der Graaf M, Barentsz JO, Ruijs SH. Proton MR spectroscopy of the normal human prostate with an endorectal coil and a double spin-echo pulse sequence. Magn Reson Med. 1997 Feb;37(2):204-13.
46. van der Sanden BP, Rijken PF, Heerschap A, Bernsen HJ, van der Kogel AJ. In vivo 31P magnetic resonance spectroscopy and morphometric analysis of the perfused vascular architecture of human glioma xenografts in nude mice. Br J Cancer. 1997;75(10):1432-8.
45. Heerschap A, Jager GJ, van der Graaf M, Barentsz JO, de la Rosette JJ, Oosterhof GO, Ruijter ET, Ruijs SH. In vivo proton MR spectroscopy reveals altered metabolite content in malignant prostate tissue. Anticancer Res. 1997 May-Jun;17(3A):1455-60.
44. Steeghs K, Heerschap A, de Haan A, Ruitenbeek W, Oerlemans F, van Deursen J, Perryman B, Pette D, Bruckwilder M, Koudijs J, Jap P, Wieringa B. Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase. J Neurosci Methods. 1997 Jan;71(1):29-41.
43. Bovee WM, Rozijn TH, Van Der Sanden BP, Heerschap A. NMR perfusion and metabolic imaging and some examples on brain tumours. Cell Mol Biol (Noisy-le-grand). 1997 Jul;43(5):675-89. Review.
42. Wevers RA, Engelke U, Rotteveel JJ, Heerschap A, De Jong JG, Abeling NG, van Gennip AH, de Abreu RA. 1H NMR spectroscopy of body fluids in patients with inborn errors of purine and pyrimidine metabolism.J Inherit Metab Dis. 1997 Jul;20(3):345-50.
41. Houston RJ, Heerschap A, Skotnicki SH, Verheugt FW, Oeseburg B. 31P content measured by 31P NMR correlates with post-ischaemic recovery of external work output in an isolated rat heart perfused with erythrocyte suspension. J Mol Cell Cardiol. 1997 Jun;29(6):1763-6.
40. Houston RJ, Skotnicki SH, Heerschap A, Oeseburg B. Coronary flow response after myocardial ischemia may predict level of functional recovery. Adv Exp Med Biol. 1997;411:121-7.
39. Houston RJ, Heerschap A, Skotnicki S, Verheugt FW, Oeseburg B. Post-ischemic 31P NMR determination of myocardial intracellular pH in vivo using ATP peak. Adv Exp Med Biol. 1997;428:253-9.
38. R. Goris, W. Kolkman, L. Leenen, I. van Bebber, F. Korstens, A. Heerschap. Symptomatologie van de posttraumatische dystrofie. Het Medisch Jaar; 165 – 177, 1997

1996

37. Negendank W, Sauter R, Brown T, Evelhoch J, Falini A, Gotsis E, Heerschap A, Kamada K, Lee B, Mengeot M, Moser E, Padavic-Shaller K, Sanders J, Spraggins T, Stillman A, Terwey B, Vogl T, Wicklow K, Zimmerman R.Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study. J Neurosurg. 1996 Mar;84(3):449-58.
36. Van Den Bergh AJ, Houtman S, Heerschap A, Rehrer NJ, Van Den Boogert HJ, Oeseburg B, Hopman MT. Muscle glycogen recovery after exercise during glucose and fructose intake monitored by 13C-NMR. J Appl Physiol. 1996 Oct;81(4):1495-500.
35. Kamm YJ, Heerschap A, Rosenbusch G, Rietjens IM, Vervoort J, Wagener DJ. 5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy. Magn Reson Med. 1996 Sep;36(3):445-50.
34. van der Graaf M, Heerschap A. Effect of Cation Binding on the Proton Chemical Shifts and the Spin-Spin Coupling Constant of Citrate. J Magn Reson B. 1996 Jul;112(1):58-62.
33. Wevers R, Engelke U, Abeling N, de Abreu R, van den Berg G, Heerschap A. 1H-NMR Spectroscopy in body fluids and leucocytes. Klin. Biochem. Metab 1996; 4 (25), 91-98.

1995

32. Cornel EB, Smits GA, Debruyne FM, Heerschap A, Schalken JA, Oosterhof GO. The effects of successive high-energy shock-wave tumor administration on tumor blood flow. Ultrasound Med Biol. 1995;21(2):243-8.
31. Cornel EB, Smits GA, de Ruijter JE, Oosterhof GO, Heerschap A, Debruyne FM, Schalken JA. In vitro proton magnetic resonance spectroscopy of four human prostate cancer cell lines. Prostate. 1995 May;26(5):275-80.
30. Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A. Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.
29. Holshouser BA, Komu M, Moller HE, Zijlmans J, Kolem H, Hinshaw DB Jr, Sonninen P, Vermathen P, Heerschap A, Masur H, et al. Localized proton NMR spectroscopy in the striatum of patients with idiopathic Parkinson's disease: a multicenter pilot study. Magn Reson Med. 1995 May;33(5):589-94.
28. Abeling NG, van Gennip AH, Bakker HD, Heerschap A, Engelke U, Wevers RA. Diagnosis of a new case of trimethylaminuria using direct proton NMR spectroscopy of urine. J Inherit Metab Dis. 1995;18(2):182-4.
27. Wevers R, Engelke U, Heerschap A. Sample choice and sample preparation for 1H-NMR spectroscopy for diagnosing inborn errors of metabolism. Clin Chem 1995; 41/7, 1055 -56.
26. van der Maazen RW, Thijssen HO, Kaanders JH, de Koster A, Keyser A, Prick MJ, Grotenhuis JA, Wesseling P, van der Kogel AJ. Conventional radiotherapy combined with carbogen breathing and nicotinamide for malignant gliomas. Radiother Oncol. 1995 May;35(2):118-22
25. Wevers R, Engelke U, Abeling N, de Abreu R, van de Berg A, Heerschap A 1H-NMR Spectroscopie in lichaamsvloeistoffen en leucocyten . Ned Tijdschr Klin Chem. (1995) 20, 3 - 9.
24. A Heerschap, JCM Zijlmans, HOM Thijssen, A. De Koster, MWIM Horstink.Proton MR spectroscopy in parkinsonism. In "New prospects in psychiatry. The bio-clinical interface". Pg 309 -315. JP Macher, MA Crocq, JF Nedelec (Eds), John Libbey Eurotext, Paris. 1995.

1994

23. Smits GA, Cornel E, van de Boogert E, Oosterhof GO, Debruyne FM, Schalken JA, Heerschap A. Effects of high energy shock waves on tumor blood flow and metabolism: 31P/1H/2H nuclear magnetic resonance study. NMR Biomed. 1994 Nov;7(7):319-26.
22. van Deursen J, Ruitenbeek W, Heerschap A, Jap P, ter Laak H, Wieringa B. Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9091-5.
21. Zijlmans JC, de Koster A, van 't Hof MA, Thijssen HO, Horstink MW, Heerschap A.Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism. Acta Neurol Scand. 1994 Dec;90(6):405-11.
20. Kamm VJ, Rietjens IM, Vervoort J, Heerschap A, Rosenbusch G, Hofs HP, Wagener DJ. Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy. Cancer Res. 1994 Aug 15;54(16):4321-6.
19. Cornel EB, Heerschap A, Smits GA, Oosterhof GO, Debruyne FM, Schalken JA. Magnetic resonance spectroscopy detects metabolic differences between seven Dunning rat prostate tumor sublines with different biological behavior. Prostate. 1994 Jul;25(1):19-28.
18. Wevers RA, Engelke U, Heerschap A. High-resolution 1H-NMR spectroscopy of blood plasma for metabolic studies. Clin Chem. 1994 Jul;40(7 Pt 1):1245-50.
17. van Deursen J, Jap P, Heerschap A, ter Laak H, Ruitenbeek W, Wieringa B. Efects of the creatine analogue beta-guanidinopropionic acid on skeletal muscles of mice deficient in muscle creatine kinase. Biochim Biophys Acta. 1994 May 18;1185(3):327-35.
16. Heerschap A, van den Berg PP. Proton magnetic resonance spectroscopy of human fetal brain Am J Obstet Gynecol. 1994 Apr;170(4):1150-1.
15. A. Heerschap. NMR: a non-invasive tool in animal experimentation. In “Animal Alternatives, Welfare and Ethics”. Eds. LFM van Zutphen and M. Balls. Developments in Animal and Veterinary Sciences 27, 303 - 309. 1994

1993

14. Cornel EB, Smits GA, Oosterhof GO, Karthaus HF, Deburyne FM, Schalken JA, Heerschap A. Characterization of human prostate cancer, benign prostatic hyperplasia and normal prostate by in vitro 1H and 31P magnetic resonance spectroscopy. J Urol. 1993 Dec;150(6):2019-24.
13. van Deursen J, Heerschap A, Oerlemans F, Ruitenbeek W, Jap P, ter Laak H, Wieringa B.Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell. 1993 Aug 27;74(4):621-31.
12. Heerschap A, den Hollander JA, Reynen H, Goris RJ. Metabolic changes in reflex sympathetic dystrophy: a 31P NMR spectroscopy study. Muscle Nerve. 1993 Apr;16(4):367-73.
11. Smits GA, Jap P, Heerschap A, Oosterhof G, Debruyne F, Schalken J. Biological effects of high energy shock waves in mouse skeletal muscle: correlation between 31P magnetic resonance spectroscopic and microscopic alterations. Ultrasound Med Biol. 1993;19(5):399-409.
10. A. Heerschap, G.A.H. Smits, H.J. van den Boogert, G.O.N. Oosterhof, F.M.J. Debruyne, J.H.J. Ruijs and J.A. Schalken. In MR Spectroscopic evaluation of the effects of high-energy shock waves administered to a human cancer xenograft. "Magnetic Resonance in Nephrourology: clinical and experimental applications". Pg 34 -39. S. Pomer, WE Hull (Eds), Springer Verlag. 1993

1992

9. Bernsen HJ, Heerschap A, van der Kogel AJ, van Vaals JJ, Prick MJ, Poels EF, Meyer J, Grotenhuis JA. Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism. J Neurooncol. 1992 Jun;13(2):119-30. Review.
8. Heerschap A. Current status of human in vivo NMR spectroscopy. Eur J Radiol. 1992 Mar-Apr;14(2):117-23. Review.
7. Bernsen HJ, Verhagen WI, de Bijl MA, Heerschap A. Magnetic resonance studies on brain dysfunction induced by organic solvents. Acta Neurol Belg. 1992;92(4):207-14.

1991

6. Smits GA, Heerschap A, Oosterhof GO, Ruys JH, Hilbers CW, Debruyne FM, Schalken JA. Early metabolic response to high energy shock waves in a human tumor kidney xenograft monitored by 31P magnetic resonance spectroscopy. Ultrasound Med Biol. 1991;17(8):791-801.
5. van Vaals JJ, Bergman AH, van den Boogert HJ, Heerschap A, van der Kogel AJ, Ruifrok AC, Bernsen HJ Non-invasive in vivo localized 1H spectroscopy of human astrocytoma implanted in rat brain: regional differences followed in time. NMR Biomed. 1991 Jun;4(3):125-32.

1989

4. Heerschap A, Luyten PR, van der Heyden J, Oosterwaal LJ, den Hollander JA. Broadband proton decoupled natural abundance 13C NMR spectroscopy of humans at 1.5 T. NMR Biomed. 1989 Sep;2(3):124-32
3. Luyten P, Bruntink G, Sloff F, Vermeulen J, van der Heijden J, den Hollander J, Heerschap A. Broadband 1H decoupling in human 31P NMR spectroscopy. NMR Biomed. 1989 ;1(4):177-83.

1988

2. Heerschap A, van Vaals JJ, Bergman AH, den Boef JH, van Gerwen PH, Gravenmade EJ.In vivo 31P NMR studies of rat salivary glands at 6.3 T. Magn Reson Med. 1988 Oct;8(2):129-4
1. Heerschap A, Bergman AH, van Vaals JJ, Wirtz P, Loermans HM, Veerkamp JH. Alterations in relative phosphocreatine concentrations in preclinical mouse muscular dystrophy revealed by in vivo NMR. NMR Biomed. 1988 Feb;1(1):27-31.

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