Marinette van der Graaf

2012-05-16T12:16:27Z

Projects:

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	\|width="100pt"\|Departments:		\|width="100pt"\|Departments:
-	\|~~Clinical Physics Laboratory of~~ Dept of ~~Paediatrics~~ (~~833~~) and Dept of ~~Radiology~~ (~~667~~)	+	\| Dept of Radiology (767) and Clinical Physics Laboratory of Dept of Paediatrics (832)
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	\|width="100pt"\|Phone number:		\|width="100pt"\|Phone number:
-	\| +31 24 3617865 / +31 24 3619061 (secr~~. Clinical Physics Lab~~.~~) / + 31 24 3614545 (secr. Radiology~~)	+	\| +31 24 3617865 / +31 24 3619061 (secr.)
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	\|width="100pt"\|Email:		\|width="100pt"\|Email:
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	== Education ==		== Education ==
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-	\|width="100pt"\|1987 – 1991 \|\| PhD student at the department of Molecular Physics at ~~the Agricultural University~~ Wageningen, The Netherlands; PhD ~~thesis defence at 2 June 1992~~	+	\|width="100pt"\|1987 – 1991 \|\| PhD student at the department of Molecular Physics at Wageningen University, The Netherlands;
		+	[http://edepot.wur.nl/201190 PhD-Thesis]
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-	\|width="100pt"\|1981 – 1988 \|\| MSc Molecular Sciences, ~~Agricultural University~~ Wageningen, The Netherlands (Cum Laude)	+	\|width="100pt"\|1981 – 1988 \|\| MSc Molecular Sciences, Wageningen University, The Netherlands (Cum Laude)
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	\|width="100pt"\|1996 \|\|''Magna cum laude'' poster prize at the 13th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Prague		\|width="100pt"\|1996 \|\|''Magna cum laude'' poster prize at the 13th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Prague
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		+	\|width="100pt"\|1988 \|\|''Cum Laude'' Graduation Molecular Sciences, Wageningen University
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	== Projects ==		== Projects ==

-	During her PhD research (~~Agricultural University~~ Wageningen) and the following four years (Leiden University and Nijmegen University) Marinette van der Graaf studied the conformation of biomolecules by multi-dimensional heteronuclear NMR. ~~Since~~ June 1995 she ~~is working at~~ the Department of Radiology of the Radboud University Nijmegen ~~Medical Center as a member of the MR spectroscopy group of Prof. Heerschap. Until December 1999~~ she ~~worked on a project involving~~ MRS ~~and dynamic Gd-enhanced MRI of the human prostate focused~~ on ~~the detection and identification of~~ prostate cancer. ~~From January 2000 till January 2003 she worked on the~~ [http://azizu.uab.es/INTERPRET/ INTERPRET] ~~project in which~~ she ~~was involved in~~ the ~~acquisition of proton MR spectra~~ of brain ~~tumors and~~ MRS ~~quality control~~. ~~Presently~~ she ~~is involved in~~ the ~~projects mentioned below~~.	+	During her PhD research (Wageningen University) and the following four years (Leiden University and Nijmegen University) Marinette van der Graaf studied the conformation of biomolecules by multi-dimensional heteronuclear NMR. In June 1995 she joined the Department of Radiology of the Radboud University Nijmegen where she started to study human metabolism by in vivo Magnetic Resonance Spectroscopy (MRS). She contributed to projects on prostate cancer, brain tumours (e.g. [http://azizu.uab.es/INTERPRET/ INTERPRET]), diabetes and hepatic steatosis. In addition, she worked on the implementation of brain MRS as a standard clinical tool to study metabolic defects.
		+	Since September 2008 she combines her work at the Dept of Radiology with a part-time position at the Clinical Physics Laboratory of the Dept of Pediatrics and in January 2011 she started her training to become a Medical Physicist.

-	* [~~[Clinical application of proton MRS of the brain~~ to ~~study metabolic defects]]~~	+	== [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=PureSearch&db=pubmed&term=van+der+Graaf+M%5BAuthor%5D+NOT+Tuijl%5BAll+Fields%5D+NOT+Grimbergen%5BAll+Fields%5D+AND+(%221990%22%5BPDAT%5D+%3A+%223000%22%5BPDAT%5D) Publications in PubMed] ==
		+	'''Publications up to May 2012'''

-	* [[A study on human brain metabolism by 1H-, 31P-,13C-MRS, and arterial spin labeling during hypoglycemic conditions to gain insight in mechanisms behind hypoglycemia unawareness. This study is a collaboration with the Department of General Internal Medicine]]	+	'''h-index = 20 (May 2012)'''

-	~~Since September 2008 Marinette works for 0~~.~~8 fte in the group of Dr. Chris~~ de ~~Korte at the Clinical Physics Laboratory of the Departement of Paediatrics~~, ~~where she performs functional research using MRI and MRS methods. In addition~~, ~~she is still part-time (0~~.1 ~~fte) employed~~ by ~~the Department of Radiology.~~	+	'''52.''' Van de Ven KCC, van der Graaf M, Tack CJ, Heerschap A, de Galan BE. Steady-state brain glucose concentrations during hypoglycemia in healthy humans and patients with Type 1 Diabetes Mellitus, accepted by Diabetes

-	~~== [http~~:~~//www~~.~~ncbi~~.~~nlm~~.~~nih~~.~~gov/sites/entrez?cmd=PureSearch&db=pubmed&term=~~van+der+Graaf+M~~%5BAuthor%5D+NOT+Tuijl%5BAll+Fields%5D+NOT+Grimbergen%5BAll+Fields%5D+AND+~~(~~%221990%22%5BPDAT%5D+%3A+%223000%22%5BPDAT%5D~~) ~~Publications~~ in ~~PubMed] ==~~	+	'''51.''' Gambarota G, Tanner M, van der Graaf M, Mulkern RV, Newbould RD. 1H-MRS of Hepatic Fat using Short TR at 3T: SNR Optimization and Fast T2 Relaxometry, MAGMA 24 (2011), 339-345.
-	'''~~Publications up to June 2010~~'''	+
		+	'''50.''' Visser ME, Lammers NM, Nederveen AJ, van der Graaf M, Heerschap A, Ackermans MT, Sauerwein HP, Stroes ES, Serlie MJ. Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia, Diabetologia 54 (2011), 2113-2121.
		+
		+	'''49.''' Van de Ven KCC, de Galan BE, van der Graaf M, Shestov AA, Henry P-G, Tack CJJ, Heerschap A. Effect of acute hypoglycemia on human cerebral glucose metabolism, measured by 13C magnetic resonance spectroscopy, Diabetes 60 (2011), 1467-1473.
		+
		+	'''48.''' Van der Graaf M, De Haan JH, Smits P, Mulder AH, Heerschap A, Tack CJ. The effect of acute exercise on glycogen synthesis rate in obese subjects studied by 13C MRS, Eur J Appl Physiol 111 (2011), 275-283.
		+
		+	'''47.''' Jansen HJ, Vervoort GM, Van der Graaf M, Tack CJ. Pronounced weight gain in insulin-treated patients with type 2 diabetes mellitus is associated with an unfavourable cardiometabolic risk profile. Neth J Med 68 (2010), 359-366.

-	'''46.''' Henneke M, Dreha-Kulaczewski S, Brockmann K, van der Graaf M, Willemsen MA, Engelke U, Dechent P, Heerschap A, Helms G, Wevers RA, Gärtner J. In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency. NMR Biomed. 2010 ~~Feb 19~~. ~~[Epub ahead of print]~~	+	'''46.''' Henneke M, Dreha-Kulaczewski S, Brockmann K, van der Graaf M, Willemsen MA, Engelke U, Dechent P, Heerschap A, Helms G, Wevers RA, Gärtner J. In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency. NMR Biomed 23 (2010), 441-446.

	'''45.''' Wijnen JP, Van der Graaf M, Scheenen TW, Klomp DW, de Galan BE, Idema AJ, Heerschap A. In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose. Magn Reson Imaging 28 (2010), 690-7.		'''45.''' Wijnen JP, Van der Graaf M, Scheenen TW, Klomp DW, de Galan BE, Idema AJ, Heerschap A. In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose. Magn Reson Imaging 28 (2010), 690-7.

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Marinette van der Graaf