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Personal information
| Name: | Dr. Marinette van der Graaf |
| Date of birth: | 13-09-1963 |
| Departments: | Dept of Radiology (767) and Clinical Physics Laboratory of Dept of Paediatrics (832) |
| Phone number: | +31 24 3617865 / +31 24 3619061 (secr.) |
| Email: | M.vanderGraaf(at)rad.umcn.nl |
Education
| 1987 – 1991 | PhD student at the department of Molecular Physics at Wageningen University, The Netherlands; |
| 1981 – 1988 | MSc Molecular Sciences, Wageningen University, The Netherlands (Cum Laude) |
Honors
| 1998 | Certificate of merit poster prize at the 15th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Geneva |
| 1996 | Magna cum laude poster prize at the 13th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Prague |
| 1988 | Cum Laude Graduation Molecular Sciences, Wageningen University |
Projects
During her PhD research (Wageningen University) and the following four years (Leiden University and Nijmegen University) Marinette van der Graaf studied the conformation of biomolecules by multi-dimensional heteronuclear NMR. In June 1995 she joined the Department of Radiology of the Radboud University Nijmegen where she started to study human metabolism by in vivo Magnetic Resonance Spectroscopy (MRS). She contributed to projects on prostate cancer, brain tumours (e.g. INTERPRET), diabetes and hepatic steatosis. In addition, she worked on the implementation of brain MRS as a standard clinical tool to study metabolic defects. Since September 2008 she combines her work at the Dept of Radiology with a part-time position at the Clinical Physics Laboratory of the Dept of Pediatrics and in January 2011 she started her training to become a Medical Physicist.
Publications in PubMed
Publications up to May 2012
h-index = 20 (May 2012)
52. Van de Ven KCC, van der Graaf M, Tack CJ, Heerschap A, de Galan BE. Steady-state brain glucose concentrations during hypoglycemia in healthy humans and patients with Type 1 Diabetes Mellitus, accepted by Diabetes
51. Gambarota G, Tanner M, van der Graaf M, Mulkern RV, Newbould RD. 1H-MRS of Hepatic Fat using Short TR at 3T: SNR Optimization and Fast T2 Relaxometry, MAGMA 24 (2011), 339-345.
50. Visser ME, Lammers NM, Nederveen AJ, van der Graaf M, Heerschap A, Ackermans MT, Sauerwein HP, Stroes ES, Serlie MJ. Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia, Diabetologia 54 (2011), 2113-2121.
49. Van de Ven KCC, de Galan BE, van der Graaf M, Shestov AA, Henry P-G, Tack CJJ, Heerschap A. Effect of acute hypoglycemia on human cerebral glucose metabolism, measured by 13C magnetic resonance spectroscopy, Diabetes 60 (2011), 1467-1473.
48. Van der Graaf M, De Haan JH, Smits P, Mulder AH, Heerschap A, Tack CJ. The effect of acute exercise on glycogen synthesis rate in obese subjects studied by 13C MRS, Eur J Appl Physiol 111 (2011), 275-283.
47. Jansen HJ, Vervoort GM, Van der Graaf M, Tack CJ. Pronounced weight gain in insulin-treated patients with type 2 diabetes mellitus is associated with an unfavourable cardiometabolic risk profile. Neth J Med 68 (2010), 359-366.
46. Henneke M, Dreha-Kulaczewski S, Brockmann K, van der Graaf M, Willemsen MA, Engelke U, Dechent P, Heerschap A, Helms G, Wevers RA, Gärtner J. In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency. NMR Biomed 23 (2010), 441-446.
45. Wijnen JP, Van der Graaf M, Scheenen TW, Klomp DW, de Galan BE, Idema AJ, Heerschap A. In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose. Magn Reson Imaging 28 (2010), 690-7.
44. Van der Graaf M. In vivo magnetic resonance spectroscopy: basic methodology and clinical applications. Eur Biophys J 39 (2010), 527-40. Review.
43. Van de Ven KC, van der Graaf M, Tack CJ, Klomp DW, Heerschap A, de Galan BE. Optimized [1-(13)C]glucose infusion protocol for 13C magnetic resonance spectroscopy at 3T of human brain glucose metabolism under euglycemic and hypoglycemic conditions. J Neurosci Methods 186 (2010), 68-71.
42. van der Graaf M, Tack CJ, de Haan JH, Klomp DW, Heerschap A. In Magnetic resonance spectroscopy shows an inverse correlation between intramyocellular lipid content in human calf muscle and local glycogen synthesis rate. NMR Biomed. 23 (2010), 133-41.
41. Kroese JM, Mooij CF, van der Graaf M, Hermus AR, Tack CJ. Pioglitazone improves insulin resistance and decreases blood pressure in adult patients with congenital adrenal hyperplasia. Eur J Endocrinol 161 (2009), 887-94.
40. Kolwijck E, Engelke UF, van der Graaf M, Heerschap A, Blom HJ, Hadfoune M, Buurman WA, Massuger LF, Wevers RA. N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumors. NMR Biomed 22 (2009), 1093-9.
39. Van der Graaf M, Julià-Sapé M, Howe FA, Ziegler A, Majós C, Moreno-Torres A, Rijpkema M, Acosta D, Opstad KS, Van der Meulen YM, Arús C, Heerschap A. MRS quality assessment in a multicentre study on MRS-based classification of brain tumours. NMR Biomed 21 (2008), 148-58.
38. Willemsen MAAP, Engelke UFH, Van der Graaf M, Wevers RA. Methylsulfonylmethane (MSM) ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid. Neuropediatrics 37 (2006), 312-14.
37. Kan HE, van der Graaf M, Klomp DWJ, Vlak MHM, Padberg GW, Heerschap A. Intake of 13C-4 creatine enables simultaneous assessment of creatine and phosphocreatine pools in human skeletal muscle by 13C MR spectroscopy. Magn Reson Med 56 (2006), 953-57.
36. Tate AR, Underwood J, Acosta DM, Julià-Sapé M, Majós C, Moreno-Torres A, Howe FA, van der Graaf M, Lefournier V, Murphy MM, Loosemore A, Ladroue C, Wesseling P, Bosson JL, Cabañas ME, Simonetti AW, Gajewicz W, Calvar J, Capdevila A, Wilkins PR, Bell BA, Rémy C, Heerschap A, Watson D, Griffiths JR, Arús C. Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra. NMR Biomed 19 (2006), 411-34.
35. Engelke UFH, Kremer B, Kluijtmans LAJ, van der Graaf M, Morava E, Loupatty FJ, Wanders RJA., Moskau D, Loss S, van den Bergh E, Wevers RA. NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism. NMR Biomed 19 (2006), 271-8.
34. Klomp DWJ, Renema WKJ, van der Graaf M, de Galan BE, Kentgens APM, Heerschap A. Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla. Magn Reson Med 55 (2006), 271-8.
33. Gambarota G, van der Graaf M, Klomp D, Mulkern RV, Heerschap A. Echo-time independent signal modulations using press sequences: A new approach to spectral editing of strongly coupled AB spin systems. J Magn Reson 177 (2005), 299-306.
32. Devos A., Simonetti AW, van der Graaf M, Lukas L, Suykens JAK, Vanhamme L, Buydens LMC, Heerschap A, van Huffel S. The use of multivariate MR imaging intensities versus metabolic data from MR spectroscopic imaging for brain tumour classification. J Magn Reson 173 (2005), 218-28.
31. van der Graaf M, Janssen SW, van Asten JJ, Hermus AR, Fred Sweep CG, Pikkemaat JA, Martens GJ, Heerschap A. Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo (1)H magnetic resonance spectroscopy. NMR Biomed 17 (2004), 405-10.
30. Devos A, Lukas L, Suykens JA, Vanhamme L, Tate AR, Howe FA, Majos C, Moreno-Torres A, van der Graaf M, Arus C, Van Huffel S. Classification of brain tumours using short echo time 1H MR spectra. J Magn Reson 170 (2004), 164-75.
29. van Dorsten FA, van der Graaf M, Engelbrecht MR, van Leenders GJ, Verhofstad A, Rijpkema M, de la Rosette JJ, Barentsz JO, Heerschap A. Combined quantitative dynamic contrast-enhanced MR imaging and (1)H MR spectroscopic imaging of human prostate cancer. J Magn Reson Imaging 20 (2004), 279-87.
28. Lukas L, Devos A, Suykens JA, Vanhamme L, Howe FA, Majos C, Moreno-Torres A, Van der Graaf M, Tate AR, Arus C, Van Huffel S. Brain tumor classification based on long echo proton MRS signals. Artif Intell Med 31 (2004), 73-89.
27. Klomp DW, van der Graaf M, Willemsen MA, van der Meulen YM, Kentgens AP, Heerschap A. Transmit/receive headcoil for optimal (1)H MR spectroscopy of the brain in paediatric patients at 3 T. MAGMA 17 (2004), 1-4.
26. Willemsen MA, Van Der Graaf M, Van Der Knaap MS, Heerschap A, Van Domburg PH, Gabreels FJ, Rotteveel JJ. MR imaging and proton MR spectroscopic studies in Sjogren-Larsson syndrome: characterization of the leukoencephalopathy. Am J Neuroradiol 25 (2004), 649-57.
25. Simonetti AW, Melssen WJ, van der Graaf M, Postma GJ, Heerschap A, Buydens LM. A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy. Anal Chem 75 (2003), 5352-61.
24. Rijpkema M, Schuuring J, Van Der Meulen Y, Van Der Graaf M, Bernsen H, Boerman R, Van Der Kogel A, Heerschap A. Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging. NMR Biomed 16 (2003), 12-8.
23. Witjes H, Rijpkema M, Van Der Graaf M, Melssen W, Heerschap A, Buydens L. Multispectral magnetic resonance image analysis using principal component and linear discriminant analysis. J Magn Reson Imaging 17 (2003), 261-9.
22. Simonetti AW, Melssen WJ, van der Graaf M, Heerschap A, Buydens LM. Automated correction of unwanted phase jumps in reference signals which corrupt MRSI spectra after eddy current correction. J Magn Reson 159 (2002), 151-7.
21. Willemsen MA, Lutt MA, Steijlen PM, Cruysberg JR, van der Graaf M, Nijhuis-van der Sanden MW, Pasman JW, Mayatepek E, Rotteveel JJ. Clinical and biochemical effects of zileuton in patients with the Sjögren-Larsson syndrome. Eur J Pediatr 160 (2001), 711-7.
20. in 't Zandt H, van Der Graaf M, Heerschap A. Common processing of in vivo MR spectra. Review. NMR Biomed 14 (2001), 224-32.
19. Engelbrecht MR, Barentsz JO, Jager GJ, van der Graaf M, Heerschap A, Sedelaar J, Aarnink R, de la Rosette JJ. Prostate cancer staging using imaging. Review. BJU International 86 Suppl. 1 (2000), 123-34.
18. van der Graaf M, Schipper RG, Oosterhof GO, Schalken JA, Verhofstad AA, Heerschap A. Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer. MAGMA 10 (2000), 153-9.
17. Witjes H, Melssen WJ, in 't Zandt HJ, van der Graaf M, Heerschap A, Buydens LM. Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets. J Magn Reson 144 (2000), 35-44.
16. Barentsz JO, Engelbrecht MR, Witjes JA, de la Rosette JJ, van der Graaf, M. MR imaging of the male pelvis. Review. Eur Radiol 9 (1999), 1722-36.
15. Van der Graaf M, van den Boogert HJ, Jager GJ, Barentsz JO, Heerschap A. Human prostate: multisection proton MR spectroscopic imaging with a single spin-echo sequence--preliminary experience. Radiology 213 (1999), 919-25.
14. Kolk MH, van der Graaf M, Fransen CT, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW. Structure of the 3'-hairpin of the TYMV pseudoknot: preformation in RNA folding. EMBO J 17 (1998), 7498-504.
13. Kolk MH, van der Graaf M, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW. NMR structure of a classical pseudoknot: interplay of single- and double-stranded RNA. Science 280 (1998), 434-8.
12. van der Graaf M, Jager GJ, Heerschap A. Removal of the outer lines of the citrate multiplet in proton MR spectra of the prostatic gland by accurate timing of a PRESS pulse sequence. MAGMA 5 (1997), 65-9.
11. Heerschap A, Jager GJ, van der Graaf M, Barentsz JO, de la Rosette JJ, Oosterhof GO, Ruijter ET, Ruijs SH. In-vivo proton MR spectroscopy reveals altered metabolite content in malignant prostate tissue. Anticancer Res 17 (1997), 1455-60.
10. Heerschap A, Jager GJ, van der Graaf M, Barentsz JO, Ruijs SH. Proton MR spectroscopy of the normal human prostate with an endorectal coil and a double spin-echo pulse sequence. Magn Reson Med 37 (1997), 204-13.
9. van der Graaf M, Heerschap A. Effect of cation binding on the proton chemical shifts and the spin-spin coupling constant of citrate, J Magn Reson Series B 112 (1996), 58-62.
8. Wijmenga SS, Heus HA, Leeuw HA, Hoppe H, van der Graaf M, Hilbers CW. Sequential backbone assignment of uniformly 13C-labeled RNAs by a two-dimensional P(CC)H-TOCSY triple resonance NMR experiment. J Biomol NMR 5 (1995), 82-6.
7. Wolfs CJ, van der Graaf M, Hemminga MA. Conformational changes in oligo-nucleotides upon binding to a peptide representing the N-terminal region of a viral coat protein. An optical spectroscopy study. Biochim Biophys Acta 1172 (1993), 1-4.
6. van der Graaf M, Scheek RM, van der Linden CC, Hemminga MA. Conformation of a pentacosapeptide representing the RNA-binding N-terminus of cowpea chlorotic mottle virus coat protein in the presence of oligophosphates: a two-dimensional proton nuclear magnetic resonance and distance geometry study. Biochemistry 31 (1992), 9177-82.
5. Van der Graaf M, Kroon GJ, Hemminga MA. Conformation and mobility of the RNA-binding N-terminal part of the intact coat protein of cowpea chlorotic mottle virus. A two-dimensional proton nuclear magnetic resonance study. J Mol Biol 220 (1991), 701-9.
4. van der Graaf M, Hemminga MA. Conformational studies on a peptide fragment representing the RNA-binding N-terminus of a viral coat protein using circular dichroism and NMR spectroscopy. Eur J Biochem 201 (1991), 489-94.
3. van der Graaf M, van Mierlo CP, Hemminga MA. Solution conformation of a peptide fragment representing a proposed RNA-binding site of a viral coat protein studied by two-dimensional NMR. Biochemistry 30 (1991),5722-7.
2. Fraaije JG, Kleijn JM, van der Graaf M, Dijt JC. Orientation of adsorbed cytochrome c as a function of the electrical potential of the interface studied by total internal reflection fluorescence. Biophys J 57 (1990), 965-75.
1. Hofstra U, van der Graaf M, Schaafsma TJ. Optical and FDMR spectroscopy of diphenyletioporphyrin. Chem Phys Letters 144 (1988), 125-30.
Contributions to books
- Engelke UFH, Moolenaar SH, Hoenderop SMGC, Morava E, Van der Graaf M, Heerschap A, Wevers RA. Handbook of 1H-NMR spectroscopy in inborn errors of metabolism: body fluid NMR spectroscopy and in vivo MR spectroscopy, 2nd edition; Heilbronn: SPS Verlagsgesellschaft (Publisher), 2007, ISBN 3-936145-49-0.
- Devos A, Van Huffel S, Simonetti AJW, Van der Graaf M, Heerschap A, Buydens L. Classification of brain tumours by pattern recognition of Magnetic Resonance Imaging and Spectroscopy data. In: A Multi-Perspective View on Outcome Prediction in Cancer (Azzam Taktak, Ed.), Elsevier Publishing Company (Publisher), 2006, chapter 8.
PhD Thesis
- Van der Graaf, M. PhD Thesis Agricultural University Wageningen: "Conformation of the RNA-binding N-terminus of the coat protein of cowpea chlorotic mottle virus. A nuclear magnetic resonance and optical spectroscopy study", 2 June 1992, ISBN 90-5485-008-6.